The Dandie Dinmont Terrier DNA Diversity Study
The Dandie Dinmont DNA Study began in 2009 and continues throughout the lifetime of many generations of Dandie Dinmonts. The study, a collaboration with Mars Corporation and Angela Hughes DVM PHD and the DDTCA, looks at several key elements. Initially the genetic diversity of the breed was determined establishing a baseline percent homozygosity. Now change in the overall breed homozygosity is monitored and results are made readily available to study participants through the DDTCA website. As the years continue we are getting good information on the effects improved genetic diversity has on our breed. We wonder if we will see a change in the incidence of disease within the breed, more stability in size and weight, alteration in number of viable puppies born per breeding and/or number of puppies surviving nesting, changes in nurturing of the dam, increased number of natural breedings, etc.
Breeders receive real information about the haplotypes on 28 chromosomes of both the sire and the dam they are considering for a mating. A computer calculates the potential homozygosity of the offspring the pair would produce. That potential includes the probable percent homozygosity, as well as the lowest and highest the breeding may produce. Dandie breeders now have a tool literally at their fingertips, that affords them the opportunity to calculate the potential genetic outcome of a breeding on a level much more specific than COI (Coefficient of Inbreeding). Of course, this in no way takes the place of doing ‘homework’ when it comes to pedigrees and phenotypical evaluations. It is perhaps even more essential than ever before that the breeder know the depth and breadth of the pedigrees in terms of structure, health and temperament.
To participate in the Dandie Diversity DNA study complete the Dandie Diversity Authorization Form available in every Mustard and Pepper magazine.
Complete the form and mail to the study liaison:
Miriam Couto, P.O. Box 1705, Woodland , WA 98674.
If you have any questions, you may contact her at firstname.lastname@example.org
The Dandie Dinmont Terrier Lymphoma Preliminary Statistics
Some folks have asked the DDTCA Genetics Committee Chairperson to look at the possibility of studying Lymphoma in the Dandie Dinmont Terrier. We are gathering data at present, if the statistics show that the number of effected Dandies is significant we will move forward toward a study.
Our first step is to determine the prevalence of Lymphoma in Dandies. To do this we will look at the number of Dandies with the disease to see if the number is statistically significant. If around 2% or more of our Dandie population is acquiring Lymphoma, we will begin designing the study to find the genetic culprit. Although this could potentially benefit other breeds, our primary focus is the Dandie Dinmont Terrier.
If you have, or ever had, a Dandie Dinmont diagnosed with Lymphoma would you please send us some information about your Dandie? All information given to the researchers will be kept confidential. Miriam Couto will assign a numerical code to all the Dandies (including the Dandies in your dog’s pedigree), and maintain the database so that researchers will get accurate information without identifying names or kennel names.
Below, you will find a consent form. Please complete and sign one for each affected Dandie. In addition, please ask your veterinarian to provide you with a copy of your Dandie’s health record, including diagnostic testing, results and treatment. As much information as you can gather and submit with the consent will all be helpful. Thank you, we know it is not easy to do.